Same here.
After serval days Alexa and Homey will lose connection again and again. In the app the corresponding dot has an exclamation mark which means it is not connected. A second one is still shown as connected with the same Account. A new connection with the Amazon account in the app has restored the connection. Also a soft reboot of Homey will restore the connection.
I.e. an account renewal or a Homey soft reboot leads to the same result that Homey and Alexa are connected again. If I now assume that a cookie is newly generated by TFA during the account renewal, how can this work without TFA input after a soft reboot? Probably only @Jamie can answer this question.