That would mean creating a separate Thread network per floor, which doesn’t sound right. You ideally want one Thread network, and in that network have enough Thread router devices (not border routers) to span all your floors. Similar to how Zigbee works.
From what I’ve read, if you have a Thread border router (of any kind), Homey-SHS should be able to pick it up and use it, provided that SHS is set up correctly (in terms of IPv6 requirements).